ETH Zurich

Postdoc position in Molecular Biology & Biophysics

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Postdoc position in Molecular Biology & Biophysics

The Wieczorek Lab at the Institute of Molecular Biology & Biophysics at ETH Zurich investigates the physical principles underlying the self-assembly of complex intracellular structures from biomolecules. The group uses the microtubule cytoskeleton as a model system. We apply state-of-the-art methods in structural biology, in vitro biochemical reconstitutions, and single molecule biophysics to understand how diverse multi-microtubule assemblies form from a common tubulin “building block”. The results of our work are important for understanding the molecular basis of diseases such as cancer and neurodegeneration, which are often directly linked to defects in microtubule network assembly.

Project background

Previously, we solved the structure of the gamma-tubulin ring complex (gamma-TuRC), a huge multiprotein assembly proposed to nucleate and organize microtubules in cells (Wieczorek, Urnavicius et al. Cell (2019)). We are broadly interested in exploring the following open questions:

1) How does the gamma-TuRC regulate microtubule architecture?
2) How do gamma-TuRC co-factors interact with and regulate the various biochemical functions of the complex?
3) How are various microtubule networks properly established and regulated by the gamma-TuRC in conjunction with tubulin and other microtubule-associated proteins?

You will have the opportunity to explore these and other fundamental cell biological questions as the basis of their postdoc project in the group. 

The group has access to state-of-the-art electron microscopy instrumentation, including FEI Vitrobots and related grid preparation facilities and three Titan Krios microscopes, all hosted and maintained at ETH Zurich’s imaging facility, ScopeM. Appropriate computational resources are also readily available within the group and through a central computational cluster at ETH Zurich.

This is a fully funded position for a maximum of 4 years with an anticipated start date of January 1st, 2023 (negotiable). Further project details will be discussed during the interview.

Job description

We are looking for an enthusiastic and highly-motivated individual to investigate how microtubules self-assemble. You will develop cutting-edge assays for determining structural snapshots of microtubule assembly at near-atomic resolution.

Your profile

  • Structural biology background with hands-on experience in cryo-EM sample preparation, data collection, image processing (using e.g. RELION, cryoSPARC) and model building (using e.g. COOT, Phenix)
  • Experience developing custom scripts in e.g. Python for data/image processing, including using deep learning libraries, are a plus
  • A PhD degree in structural biology, biochemistry, biophysics, or other disciplines related to the position is required
  • Experience with basic molecular biology, cell culturing, and/or protein purification methods are a plus
  • Curiosity about the inner workings of the cell and a passion for basic science
  • The writing of scientific papers and active participation in internal meetings and in international conferences will require a good knowledge of English

We offer

ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.

Working, teaching and research at ETH Zurich

We value diversity

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So are we.

We look forward to receiving your online application with the following documents:

  • Cover/motivation letter that demonstrates your suitability for the offered position and addresses the general research questions you have developed in the past, as well as your plans for your potential future research at ETH
  • Curriculum vitae
  • Copies of PhD (if available) degrees
  • Name and contact information of two references

Evaluation of applications will start immediately and will continue until a suitable candidate has been identified. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Further information about the Institute of Molecular Biology & Biophysics can be found on our website. For further information, please contact Prof. Dr. Michal Wieczorek, Tel +41 44 633 66 54 or email (no application documents).

About ETH Zürich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

Informatie over de vacature

Postdoc position in Molecular Biology & Biophysics
Rämistrasse 101 Zürich, Zwitserland
Uiterste sollicitatiedatum
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ETH Zurich is well known for its excellent education, ground-breaking fundamental research and for implementing its results directly into practice.

De pagina van de werkgever bekijken