The lab of Dr. Attanasio is a new research group at the Department of Human Genetics, KU Leuven (=Leuven University), the highest-ranked university in Belgium and the most innovative university in Europe. The lab performs state-of-the-art research in functional genomics to study the regulatory role of non-coding DNA in complex biological processes and supports other groups with expertise in gene regulation and genomics approaches. The goal is to understand how regulatory sequences control spatio-temporal gene expression programs and how their alteration – through nucleotide or genome structural variation –contributes to human phenotypes or diseases.
Copy-Number Variations (CNVs), which define sequence deletions or insertions of ≥50bp, have been shown to play important roles in population diversity and human diseases. Topologically Associated Domains (TADs) are fundamental regulatory units of the genome as they ensure proper gene expression regulation. Several studies have reported that genomic rearrangements such as deletion or duplication of DNA segments (i.e. CNVs) could disrupt, duplicate or shift TADs boundaries and affect human biology. In this project, we aim at identifying the effects of rare inherited CNVs in families with developmental disorders.
For this project, we are seeking a highly motivated PhD student interested in studying the intersection between structural variants, 3D chromatin architecture and human diseases using high-throughput technologies, genetics, genomics and bioinformatics.
Start date: the position will be available from 1st of November, but the starting date is negotiable.
For more information please contact Prof. dr. Catia Attanasio, mail: email@example.com.
Additional required information:
You can apply for this job no later than September 22, 2019 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.Meer informatie
|Titel||PhD Position: Chromatin Structure Analysis of Rare Inherited Copy Number Variants|
|Job location||Oude Markt 13, 3000 Leuven|
|Gepubliceerd||augustus 13, 2019|
|Sluitingsdatum||september 22, 2019|
|Vakgebieden||Bioinformatica,   Structurele biologie,   Genetica,   Menseiljke biologie  |