Employment 0.8 - 1.0 FTE
Gross monthly salary € 2,541 - € 3,247
Required background Research University Degree
Organizational unit Faculty of Science
Application deadline 23 October 2022
Metabolic reprogramming allows cancer cells to rapidly consume nutrients and produce biomass. Targeting this altered metabolism can be a very effective treatment strategy, but development in this area has been limited. Would you like to start your academic career by tackling these challenges? Then join us as a PhD candidate and help broaden our ability to design effective cancer therapeutics.
You will work on a project funded by the Dutch Cancer Society, focused on identifying metabolic vulnerabilities in triple-negative breast cancer. Your research will include both experimental ('wet-lab') and theoretical ('dry-lab') components. You will have the opportunity to design and conduct a range of experiments in 2D and 3D tissue culture using breast cancer cell lines and patient-derived organoids; develop data-driven models of metabolism and other cellular processes; computationally simulate cancer cell behaviour to predict effective therapeutic targets; and validate your predictions through experimentation. You will gain a strong foundation in the molecular and systems biology of triple-negative breast cancer, state-of-the-art omics technologies, and computational approaches to integrate multi-omics 'big data'.
You will be working in an interactive and multidisciplinary environment in the Molecular Developmental Biology group at RIMLS, under the supervision of Dr Rosemary Yu. As part of your PhD training, you will assist in one or two courses a year and supervise BSc and MSc students within the context of your project.
Your teaching load may be up to 10% of your working time.
The Radboud Institute for Molecular Life Sciences (RIMLS) is a leading interfaculty research institute of the faculties of Science (FNWI) and Medicine (Radboud university medical center). The overarching aim of RIMLS is to decipher molecular mechanisms of disease. Research areas of RIMLS-FNWI include epigenetics, stem-cell and developmental biology, and computational biology. The central research theme is regulation of gene expression during development and in health and disease. Important tools used within the institute include next-generation sequencing, mass spectrometry, single-cell (multi-omics) analysis and computational analysis and method development. To perform state-of-the-art research, RIMLS-FNWI operates its own wet-lab and computational facilities. This fundamental and applied research in medical biology and molecular life sciences has clear links to biochemical research performed at the Institute for Molecules and Materials and other institutes of the Faculty of Science as well as to more clinically oriented research programmes at departments within the Radboud university medical center. RIMLS-FNWI actively contributes to teaching activities in the Biology study programme at Radboud University. RIMLS-FNWI currently has about 50 researchers (including 30 PhD candidates and postdoctoral researchers) and provides a vibrant and international working environment. The institute actively participates in various European and worldwide consortia and collaborations.
We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 24,000 students and 5,600 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!
Work and science require good employment practices. This is reflected in Radboud University's primary and secondary employment conditions. You can make arrangements for the best possible work-life balance with flexible working hours, various leave arrangements and working from home. You are also able to compose part of your employment conditions yourself, for example, exchange income for extra leave days and receive a reimbursement for your sports subscription. And of course, we offer a good pension plan. You are given plenty of room and responsibility to develop your talents and realise your ambitions. Therefore, we provide various training and development schemes.
For questions about the position, please contact Rosemary Yu, Assistant Professor at firstname.lastname@example.org.
You can apply until 23 October 2022, exclusively using the button below. Kindly address your application to Rosemary Yu. Please fill in the application form and attach the following documents:
The first round of interviews will take place in week 44.
You would preferably begin employment on 1 January 2023.
We can imagine you're curious about our application procedure. It offers a rough outline of what you can expect during the application process, how we handle your personal data and how we deal with internal and external candidates.
Application deadline 23 October 2022
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