University of Luxembourg

R&D Specialist Position for Metabolic Research in Neurological Disorders

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The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic and in silico – with a focus on neurodegenerative processes. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists, and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary and together we contribute to science and society.

Successful candidates will join the Enzymology & Metabolism group, led by Prof. Carole Linster, which deciphers the cellular metabolism in rare and more common neurodegenerative or neurometabolic diseases. We exploit genomic and post-genomic data to fill gaps in metabolic networks, discover new enzyme functions, and elucidate their role in disease. For conserved disease genes of interest, genetic models are generated in yeast, zebrafish and/or human cells for molecular phenotyping and testing of therapeutic approaches.

Your Role...

  • Develop targeted mass spectrometry-based metabolomics methods for metabolites of interest
  • Perform targeted and untargeted mass spectrometry-based metabolomics analyses in biological samples
  • Perform stable isotope labeling-based metabolomics analyses in biological samples
  • Perform metabolomics data analysis
  • Perform transcriptomics data analysis, including from single cell RNAseq
  • Contribute to chemical identification of relevant unknown peaks using cheminformatics approaches and final validation using targeted methods
  • Set up and perform metabolic enzyme assays using various techniques
  • Design and produce recombinant plasmids for various purposes (e.g. protein overexpression, transgenesis)
  • Perform analysis of all generated experimental data, including statistics
  • Use modern data management and establish precise project documentation
  • Work in a collaborative environment, also with different service-based core platforms (e.g. sequencing, metabolomics facilities)
  • Independent drafting of project reports and grant proposals
  • Contributing to writing manuscripts for publication in high-quality journals
  • Presentation of research findings at internal, national, and international scientific meetings

What we expect from you…

  • Master’s degree in analytical chemistry, biochemistry, molecular biology, or another similar life science-related discipline
  • Experience with and strong background in metabolic biochemistry, enzymology, and molecular biology
  • Experience in mass spectrometry-based metabolomics
  • Keen interest in investigating the molecular basis of rare neurological/neurometabolic diseases
  • Strong motivation to contribute specific parts to larger projects
  • Strong computational skills, including programming
  • Solid bioinformatic and biostatistics skills
  • Excellent organizational and management skills
  • Excellent communication skills
  • Fluency in oral and written English is essential

Here’s what awaits you at the LCSB...

  • Excellent work environment with state-of-the-art infrastructure, laboratory and administrative support
  • Truly connected. We work together with hospitals and research institutes on a national and international level as well as industrial partners. Connection between science and society is very important to us. From our school lab – the Scienteens Lab – to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society’s needs and share our passion for science
  • Be part of a multicultural team. At the LCSB we have more than 50 nationalities. Throughout the year, we organise team-building events, networking activities and more

Find out more about us!

In Short...

  • Contract type: Fixed Term Contract 6 Month
  • Work hours: Full Time 40.0 Hours per Week
  • Location: Belval
  • Internal title: Research and development specialist
  • Job reference: UOL06122

How to apply...

Applications (in English) should contain the following documents:

  • A detailed Curriculum vitae including a list of publications
  • A cover letter that includes a brief description of previous research experience and the motivation for the specific advertised position
  • Copies of diploma and transcripts
  • Name and contact details of at least two referees

Early application is highly encouraged, as the applications will be processed upon reception. Please apply formally through the HR system. Applications by email will not be considered.

The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff.

In return you will get…

  • Multilingual and international character. Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR)
  • A modern and dynamic university. High-quality equipment. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure
  • A partner for society and industry. Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs …
  • Find out more about the University
  • Addresses, maps & routes to the various sites of the University

About the University of Luxembourg...

University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and has more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres focus on research in the areas of Computer Science and ICT Security, Materials Science, European and International Law, Finance and Financial Innovation, Education, Contemporary and Digital History. In addition, the University focuses on cross-disciplinary research in the areas of Data Modelling and Simulation as well as Health and System Biomedicine. Times Higher Education ranks the University of Luxembourg #3 worldwide for its “international outlook,” #20 in the Young University Ranking 2021 and among the top 250 universities worldwide.

For further information, please contact Assoc. Prof. Carole Linster (email address: carole.linster@uni.lu). Use the job title and reference number mentioned above in the subject line of your email.

Informatie over de vacature

Functienaam
R&D Specialist Position for Metabolic Research in Neurological Disorders
Locatie
2, avenue de I'Universite Belvaux, Luxemburg
Gepubliceerd
2023-11-23
Uiterste sollicitatiedatum
Unspecified
Soort functie
Baan opslaan

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The University of Luxembourg, a small-sized institution with an international reach, aims at excellence in research and education.

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