University of Twente

Post-Doc position in Systems Biology

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Job description

We offer a Post-Doc position in Systems Biology at the University of Twente (UT)

The Department of Developmental BioEngineering at the University of Twente (Enschede, the Netherlands) is looking for a computational modeler to describe and predict factors for better stem cell differentiation for heart tissue engineering applications. This project will be performed in close collaboration with the department of Mathematics of Imaging & AI (MIA) at the University of Twente.

The Challenge

Current animal and cell culture models are not accurate enough to predict the efficacy and toxicity of drugs. In this research project, titled ‘Advanced bioengineering strategy for production of human miniature hearts’, a multidisciplinary team consisting of (developmental) biologists, bioinformaticians, and mathematicians will encapsulate human stem cells in hollow miniature spheres made from hydrogel and use single cell OMICs analysis to make digital twins of the miniature hearts. The digital twins generated in this project allow investigating heart development and predicting the response of the heart to medication.

Your profile

We look for a highly motivated, enthusiastic researcher who is driven by curiosity and:

  • Has, or will shortly acquire, a PhD degree in (Applied) Mathematics, Systems Biology, or Biomedical Engineering, Bioinformatics or a related field;
  • Has experience with mathematical modelling and analysis with large-scale simulation tools and/or bifurcation analysis;
  • Has a strong interest in systems biology;
  • Experience with analysis of big data (transcriptomics, proteomics) and / or heart development will be considered a benefit;
  • Is a team player with good communication skills;
  • Has demonstrated scientific creativity that has preferably resulted in recent and relevant high-quality scientific publications in international journals
  • Is proficient in English, both spoken and written.
  • Has an interest in contributing to the education of Ba-Ma students
  • Experience in managing projects and writing project proposals will be considered a benefit.

Our offer

  • A fulltime Post-Doc position;
  • Initially employed for two years, after which your position can be extended;
  • Full status as an employee at the UT, including pension and health care benefits;
  • Gross monthly salary between € 3.557,- and € 4.670.- (depending on experience and qualifications)
  • The University of Twente provides excellent facilities for professional and personal development, a holiday allowance and an end-of-year bonus;
  • A solid pension scheme;
  • A lively and green campus with many facilities for sports and other extracurricular activities;
  • Excellent facilities for professional and personal development.
  • Your main responsibility will be to carry out research, but you will be given the opportunity to acquire some teaching experience and supervise students in Master and Bachelor projects as well.
  • Total of 41 holiday days in case of full-time employment
  • The terms of employment are in accordance with the Dutch Collective Labour Agreement for Universities (CAO)

Information and application

Are you interested to be part of our team? Please send your application and include:

  • A motivation letter explaining your interest and qualifications for this position;

  • A detailed CV (resume) with a publication list;

  • The name and e-mail address/telephone number of two references;

  • A copy of your PhD-thesis and two of your related scientific papers;

  • We may request a TOEFL or IELTS score to verify sufficient skills in English.

For inquiries about this position and our offer you can contact Janine Post, PhD ( An application for this position should be accompanied by motivation and curriculum vitae, including a list of publications (when applicable) and can be submitted via                  website

KEY WORDS: mathematical modeling, regenerative medicine, computational modeling, Heart development, stem cells, etc.

About the department

Department of Developmental BioEngineering

The department of Developmental BioEngineering is a research group with a highly international character. The main goal of this group is to investigate novel and challenging technologies in the field of Regenerative Medicine, which can be used for tissue repair. Research focuses on i) Fundamental aspects of joint and cartilage homeostasis, ii) Cell therapy for treatment of joint disorders, and iii) Injectable, in situ gelating extracellular matrices for soft tissue repair, iv) computational models for tissue development and homeostasis. website

The project will be performed in close collaboration with the department of Mathematics of Imaging & AI (MIA) at the same university (UT). This department focuses on topics in the area of dynamical systems, numerical analysis and scientific computing, and systems and control, and in particular, their relation with data science.                                          website

About the organization

The Faculty of Science & Technology (Technische Natuurwetenschappen, TNW) engages some 700 staff members and 2000 students in education and research on the cutting edge of chemical technology, applied physics and biomedical technology. Our fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally and is strengthened by the many young researchers working on innovative projects with as doctoral candidates and post-docs. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.

Informatie over de vacature

Post-Doc position in Systems Biology
Drienerlolaan 5 Enschede, Nederland
Uiterste sollicitatiedatum
Soort functie
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