UCAM-SENS FPI Predoctoral Fellowship – PhD Opportunity

Project Background: Close2Cell

The Close2Cell project addresses the growing need for innovative analytical tools that enable real-time, continuous single-cell analysis of ions and proteins. This project proposes a disruptive sensing approach based on label-free potentiometric nanosensors capable of detecting potassium, sodium, calcium, pH, chloride, bicarbonate, and Interleukin-6 (IL-6).

For IL-6 detection, the approach uniquely leverages endogenous potassium levels within cells as an indirect biomarker, using selective protein–antibody interactions to perturb potassium ion transfer across a selective membrane. This mechanism is integrated into the potentiometric sensor for indirect IL-6 quantification.

The project explores multiple innovation strategies to design and validate versatile potentiometric nanoprobes with high analytical performance tailored for single-cell applications. These sensors will be tested in artificial media, cytosolic samples, and cell-based systems using various cell lines under stimulation (e.g., pharmaceutical exposure). This approach is minimally invasive, cost-effective, and aligned with sustainable innovation in health monitoring.

Close2Cell supports Sustainable Development Goals 3 and 10, promoting Good Health and Well-Being and Reducing Inequalities. The outcomes are expected to contribute significantly to understanding cellular physiology and pathology, particularly in the context of the EU Mission: Cancer. 

Candidate Profile – Requirements

We are seeking highly motivated and qualified candidates for a PhD fellowship at UCAM-SENS. Applicants must have:

• A completed M.Sc. degree in Chemistry, Chemical Engineering, Biochemistry, Biotechnology, Nanotechnology, or related disciplines.
• Hands-on experience in one or more of the following is highly desirable:
  • (Bio)chemical sensors and electrochemistry
  • Analytical chemistry
  • Microneedle or wearable devices
  • Single-cell detection techniques
  • Conducting polymers
• Experience in cell culture is considered valuable.
• Proficiency in English (minimum level B2 or equivalent). Please attach certification. 

Please attach supporting documentation such as publications or Master’s thesis if available. 

Desired Personal Skills

At UCAM-SENS, we value candidates who are: 

• Goal-oriented and persistent
• Capable of working independently and collaboratively
• Professional in approach and communication
• Able to manage and analyze complex scientific challenges 

Beyond academic qualifications, personal motivation and suitability will be strongly considered in the selection process. 

Application Requirements

Please submit the following documents:

1. Curriculum Vitae (max. 2 pages)
   • Include academic background, professional experience, relevant skills
   • State degree titles, awarding institutions, and graduation years
2. Motivation Letter (max. 2 pages)
   • Explain your interest in UCAM-SENS and this PhD position
   • Describe how your background aligns with the project and your future goals
3. Publications or Technical Reports
   • Include abstracts and web links if documents are lengthy
4. Reference Letters
   • From previous supervisors or academic instructors

What We Offer

• A fully funded 3-year PhD position at UCAM-SENS, an international and dynamic research hub
• Integration into small, focused research clusters led by senior scientists
• Monthly salary in accordance with UCAM’s doctoral fellowships
• Assistance with relocation and settling in Murcia and at UCAM
• A supportive, innovative, and collaborative environment
• The PhD project can be customized to match your skills and interests, covering foundational chemical sensing and applications in health, sports, food, or environmental fields
• Close mentorship by Prof. Maria Cuartero

(ERC Fellow) and Prof. Gastón Crespo, internationally recognized researchers with:

• Over 200 publications (85% Q1, 80% D1)
  • 5 international patents
  • Several startup ventures

A mentorship approach focused on growth, mutual respect, and the development of scientific and interpersonal skills