Postdoctoral Research Position in Alzheimer’s disease and Tauopathies – Institute of Neuroscience, UCLouvain, Brussels

The Aging and Dementia Lab (Institute of Neuroscience) together with the MassProt group (de Duve Institute) at UCLouvain is seeking a highly motivated Postdoctoral Research Fellow to investigate the role of ubiquitination in tauopathies, including Alzheimer’s disease. This position is available starting September 1st, 2025, funded for two years with potential for renewal based on performance.

About the Project:

Our lab focuses on the molecular mechanisms underlying neurodegeneration, with a special emphasis on protein homeostasis and post-translational modifications in Alzheimer’s disease and related tauopathies. This postdoctoral project will explore in particular how changes in ubiquitin-mediated signalling and associated cellular protein degradation pathways regulate tau aggregation, clearance, and neurotoxicity.

The candidate will employ a combination of biochemical, proteomic, cellular, and in vivo approaches to dissect dynamics related to ubiquitination and their functional consequences in disease-relevant models.

Key Responsibilities:

• Design and execute experiments to study the impact of pathological ubiquitination profiles in tauopathy models (transgenic mice)
• Use techniques such as protein biochemistry and mass spectrometry, immunofluorescence and confocal microscopy, neuronal cultures, cellular and molecular biology approaches
• Analyse data and contribute to manuscript and grant preparation
• Collaborate with internal and external researchers in a highly interdisciplinary setting
• Present research at lab meetings, conferences, and seminars

Qualifications:

• Ph.D. in Neuroscience, Biochemistry, Molecular Biology, or a related field
• Experience in protein biochemistry and neurodegenerative diseases
• Strong background in molecular biology techniques and data analysis
• Solid publication record in relevant areas
• Excellent communication and problem-solving skills
• Fluent in English (written/spoken), knowledge of French is an asset.

Preferred Qualifications:

• Familiarity with Alzheimer's disease and tauopathies or neurodegenerative conditions
• Experience with protein biochemistry and viral transduction
• Background in working with neuronal cultures or mouse models

What We Offer:

• A dynamic and collaborative research environment (3 research groups from 2 institutes involved in the project)
• Access to cutting-edge core facilities and model systems
• Mentorship in research development, scientific writing, and career planning

Application Instructions:

Please send the following materials in a single PDF to:

Pascal Kienlen-Campard

[email protected]

Didier Vertommen

[email protected]

with the subject line “Postdoc Application – Ubiquitination & Tauopathies”:

• Cover letter outlining research interests, experience, and fit for the position
• Curriculum Vitae (CV)
• Contact details for 2–3 professional references
• Optional: One representative publication

Application Deadline: June 15th 2025

UCLouvain is an equal opportunity employer. We value diversity and welcome applicants from all backgrounds.