We are an international research Center in Molecular Medicine. We are affiliated at the Paris Descartes University, Inserm and CNRS. Our mission is to combine insights obtained through basic and clinical research and develop innovative therapeutic and diagnostic strategies focused on medical specialties represented in the Necker hospital. These include immune disorders, haematological diseases, infectious diseases, kidney diseases, cystic fibrosis and endocrinological disorders. Our location on the Necker campus and the close interaction between the research labs and the clinical departments is one of our major strengths creating a highly dynamic environment and allowing “from bench to bedside” activities. The research proposal of the teams are highly consistent with this mission and most groups have very tight connections with clinical departments, mostly through clinicians with joint appointments in research labs and clinical departments. For over 40 years, the development of renal transplants and bone marrow transplants, the phenotyping of autoimmune diseases and genetic diseases, allowed most of the major medical advances of today. The major asset of the Institute Necker-Enfants Malades comes from the plurality of skills, the freedom and creativity of its researchers, their desire to diversify their research topics. Translational activities will be pursued and promoted as much as possible. Indeed, this group of PIs has filed 24 patents, 4 of which are licenced to pharmaceutical companies. 13 R&D contracts have been signed with industry and 3 start-up companies incorporated with one of the above PIs as founder. To further strengthen the link with the socio-economic world, we intend to devote one floor of our research building to hosting private entities, either small companies or teams from bigger pharmaceutical industries wishing to collaborate with groups of the Necker-Enfants Malades Institute.